Application
Quinolines may be obtained by the Skraup synthesis. This involves heating aniline or a substituted aniline with glycerol in the presence of sulphuric acid, ferrous sulphate and nitrobenzene. The reaction is complex. It involves dehydration of glycerol by means of sulphuric acid to give acrolein.
Notes
Quinoline is the most privileged scaffold found in many natural products, drugs, and pharmaceutical substances . It is an important chemical moiety frequently used for the design and synthesis of large spectra of derivatives. In recent times, the quinoline nucleus has attracted many chemists as well as biologists as it is one of the key building elements for the construction of many pharmacologically active substances and drugs.
Procedure
The recommended dose initially is 600 mg followed by 300 mg doses 6, 24, and 48 h later.
Other names
QUINOLINE FOR SYNTHESIS
Packing & supply
Supply locations
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