PHTHALIMIDE FOR SYNTHESIS
Part No. RXSOL-60-6605-251
Synthesis of phthalimides. An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low temperatures (20-70˚C). The method is compatible with base labile functional groups.
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| Part number | RXSOL-60-6605-251 |
|---|---|
| Supply locations | [PHTHALIMIDE FOR SYNTHESIS] manufacturers, suppliers, exporters in Mumbai, Gandhidham, Kolkata, Varanasi, Visakhapatnam, Chennai, Fujairah, Dubai, Canada BC, Barka, Sohar, Muscat, Oman. Lab chemicals manufacturers, suppliers, exporters in India, UAE Middle East, Barka, Sohar, Muscat, Oman, Canada. [PHTHALIMIDE FOR SYNTHESIS] is available in small packing as well as in bulk. Buy premium quality [PHTHALIMIDE FOR SYNTHESIS] and other lab chemicals from one of the most trusted brands. |
| Usage unit | Box |
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Enquire NowThe Synthesis is used to get primary amines from primary alkyl halides and is named after the German scientist Siegmund Gabriel. The reaction has been generalized for applications in the alkylation of sulfonamides and imides & their deprotection in order to obtain amines.
Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-γ (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells. Based on a SAR (Structure-activity relationships) study and in silico analysis of paecilocin A-mimetic derivatives, additional N-substituted phthalimide derivatives were synthesized and evaluated for PPAR-γ agonistic activity in both murine liver Ac2F cells and in human liver HepG2 cells by luciferase assay, and for adipogenic activity in 3T3-L1 cells. Docking simulation indicated PD6 was likely to bind most strongly to the ligand binding domain of PPAR-γ by establishing crucial H-bonds with key amino acid residues.
The required doses corresponding to 300mg/kg, 100mg/kg and 30mg/kg body.
PHTHALIMIDE FOR SYNTHESIS
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